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KMID : 1011320170090010036
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Journal of Pharmacoepidemiology and Risk Management
2017 Volume.9 No. 1 p.36 ~ p.40
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A Case of Successful Desensitization of First-line Antitubercular Agents in Tuberculous Lymphadenitis Patient
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Lee Sang-Chul
Kong Na-Sil
Choi Jin-Young
Kim Sun-Young
Park Kyung-Hee
Park Jung-Won
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Abstract
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Tuberculosis remains a major public health problem worldwide. Fist-line antitubercular agents such as isoniazid, rifampin, ethambutol and pyrazinamide can considered as initial therapy. But, hypersensitivity reaction to antituberculosis drugs can occur in 4-5% of the general population which usually leads to cessation of and switching of therapy. Drug desensitization can be effective alternative to patient with drug hypersensitivity. Herein, the authors introduce a 32-year-old female in whom multiple drug hypersensitivity developed 2 weeks after the initiation of first-line antituberculosis agents (isoniazid, 300 mg; rifampin, 600 mg; pyrazinamide, 1,500 mg; and ethambutol, 800 mg). We tried one by one to resume antituberculosis treatment. After successful desensitization of all 4 first-line antitubercular agents, she’s now on the therapy without any complications.
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KEYWORD
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Desensitization, Immunologic, Drug-Related Side Effects and Adverse Reactions, Tuberculosis, Antitubercular Agents
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